Download free pharmacology powerpoint templates and themes. The pharmacology, pharmacokinetics, pharmacodynamics, antimicrobial activity, clinical safety, and current regulatory status of solithromycin. A free powerpoint ppt presentation displayed as a flash slide show on id. Macrolides mainly affect grampositive cocci and intracellular pathogens such as mycoplasma, chlamydia, and legionella. Apr 03, 2017 macrolides are a class of antibiotics derived from saccharopolyspora erythraea originally called streptomyces erythreus, a type of soilborne bacteria. View and download powerpoint presentations on macrolides ppt. You can use these pharmacology ppt in your projects and presentations. Fzx, a 41 year old white female, is seen in the outpatient department for complaints of low grade fever, cough, and mild respiratory distress. The report on antibacterial drugs market by drug class quinolones, tetracycline, sulfonamide, b lactams, macrolides, aminoglycoside, phenicols, routes of administration parenteral, enteral, distribution channel drug stores and retail pharmacies, hospital pharmacies, online sales trends analysis and forecasts up to 2023 studies the market sizes, key trends and opportunities in the. Macrolides, tetracyclines, aminoglycosides, fluoroquinolones ch. Find powerpoint presentations and slides using the power of, find free presentations research about macrolides ppt. Learn macrolides side effects antibiotics pharmacology picmonic for medicine faster and easier with picmonics unforgettable images and stories. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and wellbeing around the world.
The macrolide binding site in the exit tunnel overlaps the binding sites to which clindamycin and the streptogramins bind to. Macrolides are a class of antibiotics derived from saccharopolyspora erythraea originally called streptomyces erythreus, a type of soilborne bacteria. Winner of the standing ovation award for best powerpoint templates from presentations magazine. Macrolides are one of the most commonly used families of antibiotics, used to treat a wide variety of bacterial infections. Introduction the macrolides are a group of closely related compounds characterized by a macrocyclic lactone ring usually containing 14 or 16 atoms to which deoxysugars are attached. The pharmacology and the medicinal chemistry of macrolides have been briefly described elsewhere the links of which are just. Theyll give your presentations a professional, memorable appearance the kind of sophisticated look that todays audiences expect. Members of macrolides are erythromycin, oleandomycin, spiramycin, roxithromycin, josamycin, midecamycin, clarithromycin, azithromycin and dirithromycin.
These are antibiotics having a macrocyclic lactone ring with attached sugars. Fda briefing package, antiinfective advisory committee, april 2001. Mechanisms of resistance active efflux accounts for 80% mef gene encodes for an efflux pump which pumps the macrolide out of the cell away from the ribosome. The uncharged trna left at the donor site is released step 3, and the new 6amino acid chain with its trna shifts to the peptidyl site translocation, step 4. Tetracyclines, aminoglycosides, macrolides, and lincosamides. Macrolides antibiotics pharmacology med vids made simple duration. Pharmacology 120 julie cordts instructor pharmacology powerpoint lectures all lessons will open in a new browser window allowing easy access to this menu. Macrolides antibiotics animated presentation mechanism of action. Macrolides are actively concentrated within leukocytes, and thus are transported into the site of infection. Macrolide antibiotics are bacteriostatic drugs that contain one or more sugars, generally cladinose or desosamine. In summary, although macrolides may have an effect on airway chloride ion transport, this seems to be an acute and doserelated effect and is probably not of clinical relevance.
In this lesson, you will learn what macrolides are, what these drugs are used to treat, and what side effects. Chloramphenicol, tetracyclines, macrolides, clindamycin. Effects of macrolide antibiotics on neurally mediated contraction of. Choose from 500 different sets of pharmacology macrolides tetracyclines flashcards on quizlet. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Macrolides have been considered the drug of choice for group a streptococcal and pneumococcal infections when penicillin cannot be used. Erythromycin is the first member obtained from strain of streptomyces erythrus. Macrolide antibiotics an overview sciencedirect topics. Generally it is bacteriostatic in action but acts as bacteriocidal at higher dose. Because the macrolides are antimicrobial drugs and many of the innate. Picmonic is research proven to increase your memory retention and test scores. Macrolide antibiotics are the safest option, and might be indicated for the rare child with a neutrophilic phenotype, or if an atypical infection is suspected. Learn pharmacology macrolides tetracyclines with free interactive flashcards. Mechanism of action macrolide is a protein synthesis inhibitor.
Elimination clarithromycin is the only macrolide partially eliminated by the kidney 18% of parent and all metabolites hepatically eliminated. Macrolides pharmacology distribution extensive tissue and cellular distribution clarithromycin and azithromycin with extensive penetration minimal csf penetration elimination clarithromycin is the only macrolide partially eliminated by the kidney 18% of parent and all metabolites. Ppt nursing 3703 pharmacology powerpoint presentation. Therapeutic agents of erythromycin erythromycin ethylsuccinate prodrug with more lipophilicity longer duration of action erythromycin estolate a lipid soluble,acid stable prodrug with better oral absorption erythromycin gluceptate a watersoluble salt of glucoheptanoic acid for parentral dosage forms erythromycin. Ppt macrolide antibiotics powerpoint presentation free to. However, pneumococci with reduced penicillin sensitivity are often resistant to macrolides, and in some communities, up to 20% of s. Macrolides inhibit protein synthesis in bacteria by reversibly binding to the p site of the 50s unit of the ribosome. With the exception of tetracyclines, the binding sites for these antibiotics are on the 50s ribosomal subunit. Hence when resistance develops due to ribosomal methylation that reduces binding, all three antibiotics are similarly affected.
Macrolides bacterial targets, mechanism of action, adverse effects. Pharmacology chapter 9 tetracyclines, aminoglycosides, macrolides, and lincosamides. Macrolides are antibiotics that end in the suffix thromycin. Learn everything you need to know with our complete macrolides pharmacology guide indications, side effects, mechanism, drug interactions and all the clinical and therapeutic factors you need to know. Tetracyclines, macrolides, clindamycin, chloramphenicol. Macrolides reversibly bind to 50s subunit of the ribosomes and inhibit transpeptidation and translocation processes, resulting in premature detachment of incomplete polypeptide chains. Macrolide antibiotics such as erythromycin, clarithromycin, and azithromycin have been used widely to combat primarily.
Start studying pharmacology chapter 30 macrolides, tetracyclines, aminoglycosides, and fluoroquinolones. Ppt 20042005 principles of medical science pharmacology. Azithromycin, clarithromycin, telithromycin, tigecycline jerrym. All none of the macrolides are removed during hemodialysis variable elimination halflives 1. Bono, mda,b erythromycin, the first macrolide antibiotic discovered, has been used since the early 1950s for the treatment of upper respiratory tract and skin and soft tissue infections. Amas class iii free download as powerpoint presentation. Macrolides could therefore add a novel mechanism of action to tb combination therapy, and thereby also hold out the promise of being equally effective against mdrtb and drugsensitive tb. Macrolides accumulate within cells, suggesting that they may associate with receptors. Pharmacology chapter 9 tetracyclines, aminoglycosides.
The adobe flash plugin is needed to view this content. Tetracyclines, aminoglycosides, macrolides, and lincosamides learn with flashcards, games, and more for free. Macrolides antibiotics animated presentation mechanism of. Disinfection, sterilization, antibiotics sterilization or sterilisation refers to any process that eliminates, removes, kills, or deactivates all forms of life and other biological agents such as fungi, bacteria, viruses, spore forms, prions, unicellular eukaryotic organisms such as plasmodium, etc.
Macrolide antibiotics medical university of south carolina. Some macrolides have antibiotic or antifungal activity and are used as pharmaceutical drugs. Magee, in comprehensive medicinal chemistry ii, 2007. If your institution subscribes to this resource, and you dont have a myaccess profile, please contact your librarys reference desk for information on how to. The antibioticbinding sites are shown schematically as triangles. Macrolides antimicrobial resistance learning site for. Macrolide antibiotics do so by binding reversibly to the p site on the 50s subunit of the bacterial ribosome. Lesson on the macrolide antibiotics including erythromycin, azithromycin and clarithromycin. Jan 16, 2018 macrolides pharmacology distribution extensive tissue and cellular distribution clarithromycin and azithromycin with extensive penetration minimal csf penetration elimination clarithromycin is the only macrolide partially eliminated by the kidney 18% of parent and all metabolites.
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